Gurley, the Rams’ first-round draft pick, saw his most extensive action as a pro and his 52-yard run set up what proved to be the winning touchdown.
Nick Foles threw for three touchdowns, two after Arizona turnovers, and St. Louis’ defense held the Cardinals (3-1) to field goals on four of five trips inside the red zone.
Arizona had a third-and-2 at the Rams 43 in the final minutes, but Carson Palmer overthrew receivers on consecutive plays to turn the ball over on downs.
The Rams (2-2) are 2-0 against the NFC West.